This article examines violence as an intrinsic aspect of the human condition by integrating political philosophy, literature, and neuroscience. It explores Machiavelli’s pragmatic use of violence in statecraft, Nietzsche’s revaluation of aggression as an existential force, and McCarthy’s stark portrayal of brutality in Blood Meridian. By uniting classical thought with modern neurobiological insights, the study reveals how violence functions both as a tool for power and an evolutionary impulse, shaping cultural identity and political dynamics, while urging innovative strategies to mitigate its destructive impact.