Using medications like ibuprofen (Advil, Motrin), acetaminophen (Tylenol), and aspirin can relieve minor pain from a toothache. Using numbing pastes or gels with benzocaine can help dull the pain long enough for you to fall asleep. Anti-inflammatory drugs such as ibuprofen, Advil, Motrin or naproxen work well with dental pain because they reduce inflammation,” says Huang. Recent data has shown the combination of Advil (ibuprofen) and Tylenol (acetaminophen) is as effective as prescription opioids for tooth pain